Everyone dreams of becoming a perpetual adolescent, meaning being young forever. Although the fictional fountain of youth may be not fictional at all due to the propaganda and mushrooming medical enhancement clinics that can be found everywhere. Yet the body weakens through the passing of time. Being young in body displays agility and effervescent through and through, but as one ages he cannot cope with all the frenzies of the existing time and could succumb to weakness.

To be young is to stay alive and grow old gracefully, yet, this cannot be achieved overnight due to the many factors we are confronted with day in and day out coupled with the pollutions that this technologically-advanced universe is shrouded with. Every day is a battle for modern man to find a magical solution to prolong life.

Introduction on NMN Supplements:

Where the glitch lies that today’s generation lifespan is terribly short that it scares us out of our wits. Is it in the food that what one eats or in the pollution-infested environment where one inhabits? Or, can it be attributed to man’s careless and thoughtless ways of living? These bothersome questions allow us to ponder how we should achieve longevity of life without undergoing a knife, subjecting oneself to endless aesthetic surgeries instead of accepting that each has reached his exhausting days.

To help us fight the unknowingly hazards of the world, supplements come in different forms promising one common goal – to make us healthy. Protecting one’s health from pollutants through supplements ensure that one can live till ripe age free from insurmountable aches of joints and still be mobile despite wrinkled skin and white hair.

What is nicotinamide mononucleotide or NMN?

Belonging to the family of nucleotides found in most of the foods we eat. Just like all nucleotides, NMN is composed of three parts, namely, a nitrogenous base, a sugar, and a phosphate group and while most nucleotides are used to build DNA, NMN is used to make nicotinamide adenine dinucleotide (NAD) and fine-tune energy balance (1). The body creates NMN as an intermediate step or “precursor” to NAD and therefore, it follows that the higher NMN levels mean higher NAD levels (2).

NAD increases the body’s main energy currency (ATP), balances the circadian rhythm, and enables hundreds of enzymatic reactions – many of which delay aging (3). Indeed, nicotinamide mononucleotide (NMN) is a precursor molecule for the biosynthesis of nicotinamide adenine dinucleotide, or NAD+ (4). Such is a coenzyme that participates in the production of cellular energy and DNA repair and can also be synthesized from other precursors including nicotinamide (NAM, also called niacinamide), nicotinic acid (NA), and nicotinamide riboside (NR), which are often collectively referred to as niacin (vitamin B3) or niacin equivalents (5).

What Are The Benefits of Nicotinamide Mononucleotide?

1. Fights obesity

The National Health and Medical Research Council funded a study and published in 2017 in Science Reports revealed that 18 days of nicotinamide mononucleotide (NMN) supplementation had similar beneficial effects to nine weeks of exercise in a mouse model of maternal obesity (6). Maternal obesity refers to mice bred to have increased adiposity and liver triglycerides, and decreased glucose tolerance, liver NAD+ levels and citrate synthase activity (7). These mice were designed to be fat (and had many associated physiologic conditions associated with being fat) in order to test if NMN supplementation might have similar effects on the mice as would exercise, and result showed that it did (8). 

2. Promotes cardiovascular health

Because the human heart requires a continuous supply of ATP to fuel its muscular contractions and sustain life, interruptions in the heart’s ATP supply can impair cardiac and vascular function and contribute to the development of cardiovascular disease (9). NMN boosts cardiac ATP levels and significantly improves heart health through the enhancement of the biosynthesis of NAD+, which is an essential substrate in ATP-producing reactions (10). Thus, supplementation with NMN may even prevent myocardial infarctions or heart attacks. Additionally, NMN also reduces arterial aging and vascular dysfunction, two phenomena that play crucial roles in the pathogenesis of cardiovascular disease (11).

3. Maintains cognitive health

Nicotinamide mononucleotide (NMN) supplementation aids cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice (12). In addition, a new study with a research team including Dr. David Sinclair hypothesized that nicotinamide mononucleotide (NMN) supplementation could rescue neurovascular coupling (NVC) responses in aged mice by reducing mitochondrial oxidative stress in the microvascular endothelial cells of the brain (13).

4. Fights off aging

NMN supplement may easily boosts NAD+ levels promoting healthy aging by repair damaged DNA. Anti-aging research has shown that supplementation with NMN, a key NAD+ intermediate, is effective at mitigating age-associated metabolic decline and slowing the progression of a multitude of age-related diseases (14). The research looks into the anti-aging properties of NMN. It shows that the experiments done in human stem cells have demonstrated that providing an environment rich in NMN extends the lifespan of these cells by delaying age related decline that is a result of continued cell replication (15). These anti-aging benefits have been related to NMN’s ability to maintain a high production of NAD+ for production of energy in the cell’s mitochondria (16).

NMN supplement also has other reported benefits. It is also said to have the ability to lower cancer risk as high NAD+ levels help protect against DNA damage and oxidative stress, which are linked to cancer development (17). It also aids treat jet lag because the NAD+ helps regulate your body’s internal clock, so taking niagen may help treat jet lag or other circadian rhythm disorders by resetting your body’s internal clock (18). More so, this supplement can also promote healthy muscle aging. By raising NAD+ levels, it helped improve muscle function, strength and endurance in older mice (19).

Nicotinamide Mononucleotide Side Effects

While nicotinamide mononucleotide is yet another promising supplement in the market today, researches have been conducted to support its efficacy. Because it is still a new supplement in the market, little is known of its safety. However, studies performed so far have shown it to be very safe and non-toxic (20). Side effects are rare, but itchiness, dizziness, sweating, and nausea have been reported in some cases (21). In order to safeguard ourselves of any untoward side effects and stay in the safe zone, it is always advised to consult your physician before taking NMN.